An analytic model for developing clinical practice guidelines is a visual representation of a causal pathway showing the linkages between how the proposed key research question(s) and intervention(s) under consideration as reflected in the PICOTS (P-Patient population; I- Intervention; C- Comparator; O- Outcome; T- Timing; S- Setting) framework and to their intended outcomes that require confirmation by evidence review to support related recommendations. The linkages in the model represent critical logical premises and presumed relationships among intermediate, surrogate, and ultimate health outcomes related to a specified clinical question. Woolf, S., Schünemann, H. J., Eccles, M. P., Grimshaw, J. M., Shekelle, P. (2012). Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations. Implementation Science, 7(61). https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-7-61