eCQM Title | Appropriate Treatment for ST-Segment Elevation Myocardial Infarction (STEMI) Patients in the Emergency Department (ED) |
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eCQM Identifier (Measure Authoring Tool) | 996 | eCQM Version Number | 5.1.000 |
CBE Number | 3613e | GUID | fb8caab1-dc9e-4a95-b14f-4f5dee7c6587 |
Measurement Period | January 1, 20XX through December 31, 20XX | ||
Measure Steward | Centers for Medicare & Medicaid Services (CMS) | ||
Measure Developer | Yale New Haven Health Service Corporation/ Center for Outcomes Research and Evaluation | ||
Measure Developer | The Lewin Group | ||
Endorsed By | CMS Consensus Based Entity | ||
Description |
Percentage of emergency department (ED) encounters for patients 18 years and older with a diagnosis of ST-segment elevation myocardial infarction (STEMI) that received appropriate treatment, defined as fibrinolytic therapy within 30 minutes of ED arrival, percutaneous coronary intervention (PCI) within 90 minutes of ED arrival, or transfer within 45 minutes of ED arrival |
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Copyright |
Limited proprietary coding is contained in these specifications for user convenience. Users of proprietary code sets should obtain all necessary licenses from the owners of the code sets. This material contains SNOMED Clinical Terms(R) (SNOMED CT[R]) copyright 2004-2023 International Health Terminology Standards Development Organisation. All rights reserved. LOINC(R) copyright 2004-2023 Regenstrief Institute, Inc. CPT(R) contained in the Measure specifications is copyright 2004-2023 American Medical Association. ICD-10 is copyright 2023 World Health Organization. All Rights Reserved. |
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Disclaimer |
These performance specifications are not clinical guidelines and do not establish a standard of medical care, and have not been tested for all potential applications. THE MEASURES AND SPECIFICATIONS ARE PROVIDED "AS IS" WITHOUT WARRANTY OF ANY KIND. Due to technical limitations, registered trademarks are indicated by (R) or [R] and unregistered trademarks are indicated by (TM) or [TM]. |
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Measure Scoring | Proportion | ||
Measure Type | Process | ||
Stratification |
None |
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Risk Adjustment |
None |
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Rate Aggregation |
None |
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Rationale |
Studies have shown that delays in the treatment of acute myocardial infarction (AMI) leads to increased risk of in-hospital mortality and morbidity, with nearly two lives per 1,000 patients lost per hour of delay in treatment (Sohlpour & Yusuf, 2014; Fibrinolytic Therapy Trialists’ Collaborative Group, 1994). For patients receiving fibrinolytic therapy, the American Heart Association (AHA) estimates that 65 lives will be saved per 1,000 patients if treatment is administered within the first hour of symptom onset, and 131 lives will be saved per 1,000 patients treated if fibrinolytic therapy is delivered within the first three hours (O’Connor et al., 2010). The total ischemic time—that is, the time from onset of STEMI symptoms to the initiation of some form of reperfusion therapy—is the principal determinant of health outcomes for patients with an AMI, so timely care is essential to minimize disease morbidity and mortality. Primary PCI is the preferred treatment approach, with guidelines recommending initiation of PCI within 120 minutes from first medical contact (O’Gara et al., 2013). In situations where it is unlikely or impossible for a patient to receive primary PCI within the 120-minute timeframe, fibrinolytic therapy may be used for reperfusion and should be rapidly administered to reduce mortality and minimize morbidity; guidelines recommend that fibrinolytic therapy administration occur within 30 minutes of hospital arrival; this may also require rapid transfer for PCI (O’Gara et al., 2013). Implementation of an eCQM addressing appropriateness and effectiveness of care for STEMI patients in the ED has the potential to improve the delivery of care furthering alignment with current clinical practice guidelines, while reducing adverse health outcomes such as mortality, bleeding events, and reinfarction. Use of the proposed eCQM could also reduce burden on facilities currently measured using the chart-abstracted Fibrinolytic Therapy Received within 30 Minutes of ED Arrival (OP-2) measure and broaden the population for which performance scores could be publicly reported. |
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Clinical Recommendation Statement |
Primary PCI in STEMI: The 2013 ACCF/AHA clinical practice guideline for the management of STEMI recommends that: - "Primary PCI should be performed in patients with STEMI and ischemic symptoms of less than 12 hours’ duration." - "Primary PCI should be performed in patients with STEMI and ischemic symptoms of less than 12 hours’ duration who have contraindications to fibrinolytic therapy, irrespective of the time delay from first medical contact." Fibrinolytic Therapy when there is an Anticipated Delay to Performing Primary PCI within 120 Minutes of First Medical Contact: The 2013 American College of Cardiology Foundation (ACCF)/American Heart Association(AHA) clinical practice guideline for the management of STEMI recommends that: - "In the absence of contraindications, fibrinolytic therapy should be given to patients with STEMI and onset of ischemic symptoms within the previous 12 hours when it is anticipated that primary PCI cannot be performed within 120 minutes of first medical contact.” Transfer to a PCI-Capable Hospital after Fibrinolytic Therapy: The 2013 ACCF/AHA clinical practice guideline for the management of STEMI recommends that: - Immediate transfer to a PCI-capable hospital for coronary angiography is recommended for suitable patients with STEMI who develop cardiogenic shock or acute severe heart failure (HF), irrespective of the time delay from MI onset. - Urgent transfer to a PCI-capable hospital for coronary angiography is reasonable for patients with STEMI who demonstrate evidence of failed reperfusion or reocclusion after fibrinolytic therapy. - Transfer to a PCI-capable hospital for coronary angiography is reasonable for patients with STEMI who have received fibrinolytic therapy even when hemodynamically stable and with clinical evidence of successful reperfusion. Angiography can be performed as soon as logistically feasible at the receiving hospital, and ideally within 24 hours, but should not be performed within the first 2 to 3 hours after administration of fibrinolytic therapy. |
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Improvement Notation |
Improvement noted as an increase in the rate |
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Reference |
Reference Type: CITATION Reference Text: 'Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. (1994). Indications for fibrinolytic therapy in suspected acute myocardial infarction: Collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. The Lancet, 343(8893):311-22.' |
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Reference |
Reference Type: CITATION Reference Text: 'O’Connor RE, Brady W, Brooks SC, Diercks D, Egan J, Ghaemmaghami C, Menon V, O’Neil BJ, Travers AH, Yannapoulos D. (2010) Part 10: Acute coronary syndromes: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 122(suppl 3): S787-S817. DOI: 10.1161/CIRCULATIONAHA.110.971028.' |
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Reference |
Reference Type: CITATION Reference Text: 'O'Gara P, Kushner F, Ascheim D, Casey D, Chung M, de Lemos J, Ettinger S, Fang J, Fesmire F, Franklin B, Granger C, Krumholz H, Linderbaum J, Morrow D, Newby L, Ornato J, Ou N, Radford M, Tamis-Holland J, Tommaso C, Tracy C, Woo Y, Zhao D, Anderson J, Jacobs A, Halperin J, Albert N, Brindis R, Creager M, DeMets D, Guyton R, Hochman J, Kovacs R, Kushner F, Ohman E, Stevenson W, Yancy C. (2013). 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127(4): e362-425.' |
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Reference |
Reference Type: CITATION Reference Text: 'Sohlpour A, Yusuf SW. (2014). Fibrinolytic therapy in patients with ST-elevation myocardial infarction. Expert Rev. Cardiovasc. Early online, 1-15.' |
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Definition |
None |
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Guidance |
This eCQM is an episode-based measure and should be reported for each instance of an ED encounter during the measurement period for patients with a STEMI. This version of the eCQM uses QDM version 5.6. Please refer to the eCQI resource center (https://ecqi.healthit.gov/qdm) for more information on the QDM. |
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Transmission Format |
TBD |
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Initial Population |
All emergency department encounters for patients 18 years and older at the start of the encounter with a diagnosis of ST-segment elevation myocardial infarction (STEMI) during an Emergency Department encounter that ends during the measurement period |
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Denominator |
Equals Initial Population |
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Denominator Exclusions |
Patients with the following conditions are excluded from measure denominator: At some point during ED encounter: - Allergic reaction to alteplase, streptokinase, anistreplase, tenecteplase, or reteplase Starts before the start of ED encounter and does not end before ED encounter: - Bleeding or bleeding diathesis (excluding menses) - Known malignant intracranial neoplasm (primary or metastatic) - Known structural cerebral vascular lesion (e.g., arteriovenous malformation) - Advanced dementia - Pregnancy - Diagnosis of allergy to thrombolytics At the start of ED encounter, or most recent dose within 90 days or less of ED encounter: -Active oral anticoagulant therapy Occurs 24 hours or less before start of ED encounter or during ED encounter: - Aortic dissection or ruptured aortic aneurysm - Severe neurologic impairment - Mechanical circulatory assist device placement, including: aortic balloon pump, biventricular assist device, intra-aortic balloon, intra-aortic balloon counterpulsation, intra-aortic counterpulsation balloon pump, left ventricular device, percutaneous ventricular assist device, or ventricular assist device - Intubation, including endotracheal intubation, mechanical ventilation, nasotracheal intubation, or orotracheal intubation - Cardiopulmonary arrest, including: cardiac arrest, cardiopulmonary resuscitation (CPR), defibrillation, respiratory arrest, or ventricular fibrillation (V-fib), ventricular tachycardia (VT), or pulseless electrical activity (PEA); or, traumatic or prolonged (>10 minutes) CPR Occurs 21 days or less before start of or starts during ED encounter: - Major surgery Occurs 90 days before start of or at start of ED encounter: - Ischemic stroke - Significant facial and/or closed head trauma - Peptic ulcer Occurs 90 days or less before start of ED encounter: - Intracranial or intraspinal surgery With a discharge disposition of patient expired in the ED |
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Numerator |
Emergency department encounters with a diagnosis of STEMI: - where time from ED arrival to fibrinolysis is 30 minutes or fewer; OR - where PCI is performed within 90 minutes of arrival; OR - where the patient is transferred within 45 minutes of ED arrival |
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Numerator Exclusions |
Not Applicable |
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Denominator Exceptions |
Emergency department encounters where the patient received fibrinolytic therapy at another facility within 24 hours. |
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Supplemental Data Elements |
For every patient evaluated by this measure also identify payer, race, ethnicity and sex |
"ED Encounter with STEMI Diagnosis" EDwSTEMI where AgeInYearsAt(date from start of EDwSTEMI.relevantPeriod) >= 18
"Initial Population"
"Allergy or Intolerance to Thrombolytic Medications Overlaps ED Encounter" union "Adverse Effect to Thrombolytic Medications Before End of ED Encounter" union "Active Exclusion Diagnosis at Start of ED Encounter" union "Active Oral Anticoagulant Medication at the Start of ED Encounter" union "Exclusion Diagnosis During ED Encounter or Within 24 Hours of ED Encounter Start" union "Major Surgical Procedure 21 Days or Less Before Start of or Starts During ED Encounter" union "Intubation or Mechanical Circulatory Assist Procedure During ED Encounter or Within 24 Hours of ED Encounter Start" union "Active Exclusion Diagnosis Within 90 Days Before or At the Start of ED Encounter" union "Intracranial or Intraspinal Procedure 90 Days or Less Before Start of ED Encounter" union "ED Encounter with Discharge Disposition as Patient Expired"
( "Fibrinolytic Therapy Within 30 Minutes of Arrival" union "PCI within 90 Minutes of Arrival" union "ED Departure with Transfer to Acute Care Facility Within 45 Minutes of Arrival" )
None
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Diagnosis": "Status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility"] ) TPA such that TPA.prevalencePeriod starts during EDwSTEMI.relevantPeriod
None
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Diagnosis": "Active Bleeding Excluding Menses or Bleeding Diathesis"] union ["Diagnosis": "Malignant Intracranial Neoplasm Group"] union ["Diagnosis": "Cerebral Vascular Lesion"] union ["Diagnosis": "Dementia and Related Intracranial Pathologies"] union ["Diagnosis": "Pregnant State"] union ["Diagnosis": "Allergy to thrombolytics"] ) ActiveExclusionDx such that ActiveExclusionDx.prevalencePeriod overlaps before EDwSTEMI.relevantPeriod
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Diagnosis": "Ischemic Stroke"] union ["Diagnosis": "Closed Head and Facial Trauma"] union ["Diagnosis": "Acute Peptic Ulcer"] ) DxExclusion such that ( DxExclusion.prevalencePeriod starts during Interval[start of EDwSTEMI.relevantPeriod - 90 days, start of EDwSTEMI.relevantPeriod])
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Medication, Active": "Oral Anticoagulant Medications"] OralAnticoagulant such that ( Global."HasStart" ( OralAnticoagulant.relevantPeriod ) and OralAnticoagulant.relevantPeriod starts before or on start of EDwSTEMI.relevantPeriod and OralAnticoagulant.relevantPeriod ends on or after start of EDwSTEMI.relevantPeriod ) or ( OralAnticoagulant.relevantDatetime 90 days or less before or on EDwSTEMI.relevantPeriod )
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Adverse Event": "Thrombolytic medications"] ThrombolyticAdverseEvent such that ThrombolyticAdverseEvent.type in "Thrombolytics Adverse Event" and ThrombolyticAdverseEvent.relevantDatetime before end of EDwSTEMI.relevantPeriod
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Allergy/Intolerance": "Thrombolytic medications"] ThrombolyticAllergy such that ThrombolyticAllergy.prevalencePeriod overlaps EDwSTEMI.relevantPeriod
"Initial Population"
"Allergy or Intolerance to Thrombolytic Medications Overlaps ED Encounter" union "Adverse Effect to Thrombolytic Medications Before End of ED Encounter" union "Active Exclusion Diagnosis at Start of ED Encounter" union "Active Oral Anticoagulant Medication at the Start of ED Encounter" union "Exclusion Diagnosis During ED Encounter or Within 24 Hours of ED Encounter Start" union "Major Surgical Procedure 21 Days or Less Before Start of or Starts During ED Encounter" union "Intubation or Mechanical Circulatory Assist Procedure During ED Encounter or Within 24 Hours of ED Encounter Start" union "Active Exclusion Diagnosis Within 90 Days Before or At the Start of ED Encounter" union "Intracranial or Intraspinal Procedure 90 Days or Less Before Start of ED Encounter" union "ED Encounter with Discharge Disposition as Patient Expired"
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( Global."HospitalDepartureTime" ( EDwSTEMI ) ) Departure such that Departure 45 minutes or less after Global."EmergencyDepartmentArrivalTime" ( EDwSTEMI ) and EDwSTEMI.dischargeDisposition in "Discharge To Acute Care Facility"
["Encounter, Performed": "Emergency Department Evaluation and Management Visit"] EDEncounter where EDEncounter.relevantPeriod ends during day of "Measurement Period"
"ED Encounter During MP" EDEncounter with ["Diagnosis": "STEMI"] DxSTEMI such that DxSTEMI.prevalencePeriod starts during EDEncounter.relevantPeriod
"ED Encounter with STEMI Diagnosis" EDwSTEMI where EDwSTEMI.dischargeDisposition in "Patient Expired"
"ED Encounter During MP" EDEncounter with EDEncounter.diagnoses EncounterDiagnosis such that EncounterDiagnosis.code in "STEMI"
"ED Encounter with Encounter Diagnosis of STEMI" union "ED Encounter with Diagnosis of STEMI"
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Diagnosis": "Aortic Dissection or Ruptured Aortic Aneurysm"] union ["Diagnosis": "Neurologic impairment"] union ["Diagnosis": "Cardiopulmonary Arrest"] ) ExclusionDx such that ( ExclusionDx.prevalencePeriod starts during EDwSTEMI.relevantPeriod or ExclusionDx.prevalencePeriod starts 24 hours or less before start of EDwSTEMI.relevantPeriod )
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Medication, Administered": "Fibrinolytic Therapy"] Fibrinolytic such that Global."NormalizeInterval" ( Fibrinolytic.relevantDatetime, Fibrinolytic.relevantPeriod ) starts 30 minutes or less after Global."EmergencyDepartmentArrivalTime" ( EDwSTEMI )
"ED Encounter with STEMI Diagnosis" EDwSTEMI where AgeInYearsAt(date from start of EDwSTEMI.relevantPeriod) >= 18
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Procedure, Performed": "Intracranial or Intraspinal surgery"] CranialorSpinalSurgery such that Global."NormalizeInterval" ( CranialorSpinalSurgery.relevantDatetime, CranialorSpinalSurgery.relevantPeriod ) starts 90 days or less before start of EDwSTEMI.relevantPeriod
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Procedure, Performed": "Endotracheal Intubation"] union ["Procedure, Performed": "Insertion or Replacement of Mechanical Circulatory Assist Device"] ) AirwayProcedure such that ( Global."NormalizeInterval" ( AirwayProcedure.relevantDatetime, AirwayProcedure.relevantPeriod ) starts during EDwSTEMI.relevantPeriod or Global."NormalizeInterval" ( AirwayProcedure.relevantDatetime, AirwayProcedure.relevantPeriod ) starts 24 hours or less before start of EDwSTEMI.relevantPeriod )
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Procedure, Performed": "Major Surgical Procedure"] MajorSurgery such that Global."NormalizeInterval" ( MajorSurgery.relevantDatetime, MajorSurgery.relevantPeriod ) starts 21 days or less before start of EDwSTEMI.relevantPeriod or Global."NormalizeInterval" ( MajorSurgery.relevantDatetime, MajorSurgery.relevantPeriod ) starts during EDwSTEMI.relevantPeriod
( "Fibrinolytic Therapy Within 30 Minutes of Arrival" union "PCI within 90 Minutes of Arrival" union "ED Departure with Transfer to Acute Care Facility Within 45 Minutes of Arrival" )
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ["Procedure, Performed": "Percutaneous Coronary Intervention"] PCI such that Global."NormalizeInterval" ( PCI.relevantDatetime, PCI.relevantPeriod ) starts 90 minutes or less after Global."EmergencyDepartmentArrivalTime" ( EDwSTEMI )
"ED Encounter with STEMI Diagnosis" EDwSTEMI with ( ["Diagnosis": "Status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility"] ) TPA such that TPA.prevalencePeriod starts during EDwSTEMI.relevantPeriod
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
start of First(("HospitalizationLocations"(Encounter))HospitalLocation where HospitalLocation.code in "Emergency Department Visit" sort by start of locationPeriod ).locationPeriod
not ( start of period is null or start of period = minimum DateTime )
end of Last(("HospitalizationLocations"(Encounter))HospitalLocation sort by start of locationPeriod ).locationPeriod
Encounter Visit let EDVisit: Last(["Encounter, Performed": "Emergency Department Visit"] LastED where LastED.relevantPeriod ends 1 hour or less on or before start of Visit.relevantPeriod sort by end of relevantPeriod ) return if EDVisit is null then Visit.facilityLocations else flatten { EDVisit.facilityLocations, Visit.facilityLocations }
if pointInTime is not null then Interval[pointInTime, pointInTime] else if period is not null then period else null as Interval<DateTime>
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
Measure Set |
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