eCQM Title | Antidepressant Medication Management |
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eCQM Identifier (Measure Authoring Tool) | 128 | eCQM Version Number | 13.0.000 |
CBE Number | Not Applicable | GUID | 8924f2b3-ec06-4650-b634-d70a53dee577 |
Measurement Period | January 1, 20XX through December 31, 20XX | ||
Measure Steward | National Committee for Quality Assurance | ||
Measure Developer | National Committee for Quality Assurance | ||
Endorsed By | None | ||
Description |
Percentage of patients 18 years of age and older who were treated with antidepressant medication, had a diagnosis of major depression, and who remained on an antidepressant medication treatment. Two rates are reported. a. Percentage of patients who remained on an antidepressant medication for at least 84 days (12 weeks). b. Percentage of patients who remained on an antidepressant medication for at least 180 days (6 months). |
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Copyright |
This Physician Performance Measure (Measure) and related data specifications are owned and were developed by the National Committee for Quality Assurance (NCQA). NCQA is not responsible for any use of the Measure. NCQA makes no representations, warranties, or endorsement about the quality of any organization or physician that uses or reports performance measures and NCQA has no liability to anyone who relies on such measures or specifications. NCQA holds a copyright in the Measure. The Measure can be reproduced and distributed, without modification, for noncommercial purposes (e.g., use by healthcare providers in connection with their practices) without obtaining approval from NCQA. Commercial use is defined as the sale, licensing, or distribution of the Measure for commercial gain, or incorporation of the Measure into a product or service that is sold, licensed or distributed for commercial gain. All commercial uses or requests for modification must be approved by NCQA and are subject to a license at the discretion of NCQA. (C) 2012-2024 National Committee for Quality Assurance. All Rights Reserved. Limited proprietary coding is contained in the Measure specifications for user convenience. Users of proprietary code sets should obtain all necessary licenses from the owners of the code sets. NCQA disclaims all liability for use or accuracy of any third-party codes contained in the specifications. CPT(R) codes, descriptions and other data are copyright 2024. American Medical Association. All rights reserved. CPT is a trademark of the American Medical Association. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein. Applicable FARS/DFARS restrictions apply to government use. Some measure specifications contain coding from LOINC(R) (http://loinc.org). The LOINC table, LOINC codes, LOINC panels and form file, LOINC linguistic variants file, LOINC/RSNA Radiology Playbook, and LOINC/IEEE Medical Device Code Mapping Table are copyright 2004-2024 Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee, and are available at no cost under the license at http://loinc.org/terms-of-use. This material contains SNOMED Clinical Terms(R) (SNOMED CT[R]) copyright 2004-2023 International Health Terminology Standards Development Organisation. ICD-10 copyright 2024 World Health Organization. All Rights Reserved. Some measures use RxNorm, a standardized nomenclature and coding for clinical drugs and drug delivery devices, which is made publicly available courtesy of the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services. NLM is not responsible for the measures and does not endorse or recommend this or any other product. “HL7” is the registered trademark of Health Level Seven International. |
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Disclaimer |
The performance Measure is not a clinical guideline and does not establish a standard of medical care, and has not been tested for all potential applications. THE MEASURE AND SPECIFICATIONS ARE PROVIDED "AS IS" WITHOUT WARRANTY OF ANY KIND. Due to technical limitations, registered trademarks are indicated by (R) or [R] and unregistered trademarks are indicated by (TM) or [TM]. |
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Measure Scoring | Proportion | ||
Measure Type | Process | ||
Stratification |
None |
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Risk Adjustment |
None |
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Rate Aggregation |
None |
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Rationale |
Depression affects over 17 million adults in the U.S. (NIMH, 2021) and is estimated to affect nearly a quarter of adults in their lifetime (Burcusa & Iacono, 2007). Symptoms of depression include disturbances in appetite and sleep, anxiety, decreased concentration, and suicidal ideation (NAMI, 2017; Charbonneau et al., 2005). When left untreated, depression can have a dramatic effect on one’s quality of life, causing constant feelings of hopelessness, loss of interest in daily activities and in some cases suicidal ideation (SAMHSA, 2014). The American Psychiatric Association (APA) recommends use of antidepressant medication and behavioral therapies, such as psychotherapy, for the treatment and management of depression (APA, 2010). For the past 60 years, antidepressant medication has proven to be effective, especially for patients with more severe symptoms (Fournier et al., 2010). However, studies analyzing adherence to antidepressant medications found that prevalence of nonadherence was high, ranging from 13 percent to 55.7 percent (Sansone, 2012). Clinical guidelines for depression emphasize the importance of effective clinical management in increasing patients’ medication compliance, monitoring treatment effectiveness, and identifying and managing side effects. If pharmacological treatment is initiated, appropriate dosing and continuation of therapy through the acute and continuation phases decrease recurrence of symptoms. Thus, the evaluation of the duration of pharmacological treatment serves as an important indicator in understanding patient compliance with establishing and maintaining an effective medication regimen. |
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Clinical Recommendation Statement |
American Psychological Association (2019): - "For initial treatment of adult patients with depression, the panel recommends the following in the context of sharing decision-making with the patient when considering options: 1. That clinicians offer either psychotherapy or second-generation antidepressant. 2. If considering combined treatment, the panel recommends cognitive-behavioral therapy or interpersonal psychotherapy plus a second-generation antidepressant.” - “For initial treatment of older adult patients with depression, the panel recommends the following in the context of shared decision-making with the patient: 1. Either group life review treatment or Group Cognitive Behavioral Therapy (either alone or added to usual care) over no treatment 2. Combined pharmacotherapy and interpersonal psychotherapy (IPT) over IPT alone. Of note, while the study upon which this is based used nortriptyline, the panel recommends a second-generation antidepressant due to the reduced risk of side effects.” American Psychiatric Association (2010): - “An antidepressant medication is recommended as an initial treatment choice for patients with mild to moderate major depressive disorder [I: Recommended with substantial clinical confidence] and definitely should be provided for those with severe major depressive disorder unless electroconvulsive therapy (ECT) is planned [I: Recommended with substantial clinical confidence].” - "Patients should be given a realistic notion of what can be expected during the different phases of treatment, including the likely time course of symptom response and the importance of adherence for successful treatment and prophylaxis [I]." - "During the acute phase of treatment, patients should be carefully and systematically monitored on a regular basis to assess their response to pharmacotherapy, identify the emergence of side effects (e.g., gastrointestinal symptoms, sedation, insomnia, activation, changes in weight, and cardiovascular, neurological, anticholinergic, or sexual side effects), and assess patient safety [I]." - “During the continuation phase of treatment, the patient should be carefully monitored for signs of possible relapse [I: Recommended with substantial clinical confidence]. Systematic assessment of symptoms, side effects, adherence, and functional status is essential [I: Recommended with substantial clinical confidence], and may be facilitated through the use of clinician- and/or patient-administered rating scales [II: Recommended with moderate clinical confidence]. To reduce the risk of relapse, patients who have been treated successfully with antidepressant medications in the acute phase should continue treatment with these agents for 4–9 months [I: Recommended with substantial clinical confidence].” Department of Veterans Affairs, and Health Affairs, Department of Defense (2022): - “For patients with major depressive disorder (MDD), we suggest using a quantitative measure of depression severity in the initial treatment planning and to monitor treatment progress at regular intervals to guide shared treatment decision making.” [Weak For] - “In patients with MDD who achieve remission with antidepressant medication, we recommend continuation of antidepressants at the therapeutic dose for at least six months to decrease risk of relapse.” [Strong For] Department of Veterans Affairs, and Health Affairs, Department of Defense (2016): - ”In patients at high risk for recurrent depressive episodes and who are treated with pharmacotherapy, we recommend offering maintenance pharmacotherapy for at least 12 months and possibly indefinitely.” [Strong For] - “After initiation of therapy or a change in treatment, we recommend monitoring patients at least monthly until the patient achieves remission. At minimum, assessments should include a measure of symptoms, adherence to medication and psychotherapy, and emergence of adverse effects.” [Strong For] - “In patients with MDD who achieve remission with antidepressant medication, we recommend continuation of antidepressants at the therapeutic dose for at least six months to decrease risk of relapse.” [Strong For] |
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Improvement Notation |
Higher score indicates better quality |
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Reference |
Reference Type: CITATION Reference Text: 'American Psychiatric Association. (2010). Practice guideline for the treatment of patients with major depressive disorder, 3rd edition. Arlington: Author.' |
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Reference |
Reference Type: CITATION Reference Text: 'American Psychological Association. (2019). Clinical practice guideline for the treatment of depression across three age cohorts. Retrieved from https://www.apa.org/depression-guideline' |
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Reference |
Reference Type: CITATION Reference Text: 'Burcusa, S. L., & Iacono, W. G. (2007). Risk for recurrence in depression. Clinical Psychology Review, 27(8), 959-985.' |
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Reference |
Reference Type: CITATION Reference Text: 'Charbonneau, A., Bruning, W., Titus-Howard, T., et al. (2005). The community initiative on depression: report from a multiphase work site depression intervention. Journal of Occupational and Environmental Medicine, 47(1), 60-67.' |
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Reference |
Reference Type: CITATION Reference Text: 'Department of Veterans Affairs and the Department of Defense (VA/DoD). (2022). VA/DoD Clinical Practice Guidelines for the Management of Major Depressive Disorder. Version 4.0 . Retrieved from https://www.healthquality.va.gov/guidelines/MH/mdd/VADoDMDDCPGFinal508.pdf' |
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Reference |
Reference Type: CITATION Reference Text: 'Department of Veterans Affairs and the Department of Defense (VA/DoD). (2016). VA/DoD Clinical Practice Guidelines for the Management of Major Depressive Disorder. The Management of Major Depressive Disorder Working Group. Retrieved from https://www.healthquality.va.gov/guidelines/MH/mdd/VADoDMDDCPGFINAL82916.pdf' |
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Reference |
Reference Type: CITATION Reference Text: 'Fournier, J. C., DeRubeis, R. J., Hollon, S. D., et al. (2010). Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA, 303(1), 47-53.' |
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Reference |
Reference Type: CITATION Reference Text: 'National Alliance on Mental Illness (NAMI). (2017). Depression. Retrieved from https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Depression' |
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Reference |
Reference Type: CITATION Reference Text: 'National Institute of Mental Health (NIMH). (2021). Major Depression. Retrieved from https://www.nimh.nih.gov/health/statistics/major-depression' |
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Reference |
Reference Type: CITATION Reference Text: 'Sansone, R. A., & Sansone, L. A. (2012). Antidepressant adherence: are patients taking their medications? Innovations in Clinical Neuroscience, 9(5–6), 41–46.' |
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Reference |
Reference Type: CITATION Reference Text: 'Substance Abuse and Mental Health Services Administration (SAMHSA). (2014). Results from the 2013 National Survey on Drug Use and Health: Mental Health Findings, NSDUH Series H-49, HHS Publication No. (SMA) 14-4887. Rockville, MD: Substance Abuse and Mental Health Services Administration.' |
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Definition |
Intake Period: The 12-month window starting on May 1 of the year prior to the measurement period and ending on April 30 of the measurement period. Index Prescription Start Date (IPSD): The date of the earliest prescription dispensing event for an antidepressant medication during the Intake Period. The "continuous treatment" described in this measure allows for gaps in medication treatment up to a total 31 days during the 115-day period (numerator 1) or 52 days during the 232-day period (numerator 2). Gaps can include either gaps used to change medication, or treatment gaps to refill the same medication. |
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Guidance |
To identify new treatment episodes for major depression, there must be a 105-day negative medication history (a period during which the patient was not taking antidepressant medication) prior to the dispensing event associated with the IPSD. This eCQM is a patient-based measure. This version of the eCQM uses QDM version 5.6. Please refer to the eCQI resource center (https://ecqi.healthit.gov/qdm) for more information on the QDM. |
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Transmission Format |
TBD |
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Initial Population |
Patients 18 years of age and older as of the IPSD who were dispensed antidepressant medications during the Intake Period, and were diagnosed with major depression 60 days prior to, or 60 days after the dispensing event and had a visit 60 days prior to, or 60 days after the dispensing event |
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Denominator |
Equals Initial Population |
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Denominator Exclusions |
Exclude patients who are in hospice care for any part of the measurement period. Patients who were actively on an antidepressant medication in the 105 days prior to the IPSD. |
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Numerator |
Numerator 1: Patients who have received antidepressant medication for at least 84 days (12 weeks) of continuous treatment beginning on the IPSD through 114 days after the IPSD (115 total days). Numerator 2: Patients who have received antidepressant medications for at least 180 days (6 months) of continuous treatment beginning on the IPSD through 231 days after the IPSD (232 total days). |
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Numerator Exclusions |
Not Applicable |
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Denominator Exceptions |
None |
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Supplemental Data Elements |
For every patient evaluated by this measure also identify payer, race, ethnicity and sex |
AgeInYearsAt(date from "IPSD") >= 18 and "Has IPSD and Major Depression Diagnosis" and exists "Qualifying Encounters"
"Initial Population"
Hospice."Has Hospice Services" or exists ( ["Medication, Active": "Antidepressant Medication"] ActiveAntidepressant where "IPSD" is not null and Global."ToDateInterval" ( ActiveAntidepressant.relevantPeriod ) overlaps Interval["IPSD" - 105 days, "IPSD" ) )
"Cumulative Medication Duration Greater Than or Equal to 84 Days"
None
None
None
AgeInYearsAt(date from "IPSD") >= 18 and "Has IPSD and Major Depression Diagnosis" and exists "Qualifying Encounters"
"Initial Population"
Hospice."Has Hospice Services" or exists ( ["Medication, Active": "Antidepressant Medication"] ActiveAntidepressant where "IPSD" is not null and Global."ToDateInterval" ( ActiveAntidepressant.relevantPeriod ) overlaps Interval["IPSD" - 105 days, "IPSD" ) )
"Cumulative Medication Duration Greater Than or Equal to 180 Days"
None
None
None
["Medication, Dispensed": "Antidepressant Medication"] Antidepressant let MedicationPeriod: CMD."MedicationDispensedPeriod" ( Antidepressant ) return MedicationPeriod intersect Interval["IPSD", "IPSD" + 114 days]
["Medication, Dispensed": "Antidepressant Medication"] Antidepressant let MedicationPeriod: CMD."MedicationDispensedPeriod" ( Antidepressant ) return MedicationPeriod intersect Interval["IPSD", "IPSD" + 231 days]
DateTime((year from start of "Measurement Period"), 4, 30, 23, 59, 59, 0, 0)
CMD."CumulativeDuration" ( "Antidepressant Medication Period Between IPSD and 231 Days After IPSD" ) >= 180
CMD."CumulativeDuration" ( "Antidepressant Medication Period Between IPSD and 114 Days After IPSD" ) >= 84
"Initial Population"
Hospice."Has Hospice Services" or exists ( ["Medication, Active": "Antidepressant Medication"] ActiveAntidepressant where "IPSD" is not null and Global."ToDateInterval" ( ActiveAntidepressant.relevantPeriod ) overlaps Interval["IPSD" - 105 days, "IPSD" ) )
First(["Medication, Dispensed": "Antidepressant Medication"] Antidepressant where start of Global."NormalizeInterval"(Antidepressant.relevantDatetime, Antidepressant.relevantPeriod) in day of "Intake Period" sort by start of Global."NormalizeInterval"(relevantDatetime, relevantPeriod) )
exists ( ["Diagnosis": "Major Depression"] MajorDepression where "IPSD" is not null and date from start of MajorDepression.prevalencePeriod within 60 days of "IPSD" )
exists ( ["Encounter, Performed": "Encounter Inpatient"] InpatientEncounter where ( InpatientEncounter.dischargeDisposition ~ "Discharge to home for hospice care (procedure)" or InpatientEncounter.dischargeDisposition ~ "Discharge to healthcare facility for hospice care (procedure)" ) and InpatientEncounter.relevantPeriod ends during day of "Measurement Period" ) or exists ( ["Encounter, Performed": "Hospice Encounter"] HospiceEncounter where HospiceEncounter.relevantPeriod overlaps day of "Measurement Period" ) or exists ( ["Assessment, Performed": "Hospice care [Minimum Data Set]"] HospiceAssessment where HospiceAssessment.result ~ "Yes (qualifier value)" and Global."NormalizeInterval" ( HospiceAssessment.relevantDatetime, HospiceAssessment.relevantPeriod ) overlaps day of "Measurement Period" ) or exists ( ["Intervention, Order": "Hospice Care Ambulatory"] HospiceOrder where HospiceOrder.authorDatetime during day of "Measurement Period" ) or exists ( ["Intervention, Performed": "Hospice Care Ambulatory"] HospicePerformed where Global."NormalizeInterval" ( HospicePerformed.relevantDatetime, HospicePerformed.relevantPeriod ) overlaps day of "Measurement Period" ) or exists ( ["Diagnosis": "Hospice Diagnosis"] HospiceCareDiagnosis where HospiceCareDiagnosis.prevalencePeriod overlaps day of "Measurement Period" )
AgeInYearsAt(date from "IPSD") >= 18 and "Has IPSD and Major Depression Diagnosis" and exists "Qualifying Encounters"
Interval["May 1 of the Year Prior to the Measurement Period", "April 30 of the Measurement Period"]
date from start of Global."NormalizeInterval" ( "Earliest Antidepressant Dispensed During Intake Period".relevantDatetime, "Earliest Antidepressant Dispensed During Intake Period".relevantPeriod )
DateTime((year from start of "Measurement Period" - 1), 5, 1, 0, 0, 0, 0, 0)
"Cumulative Medication Duration Greater Than or Equal to 84 Days"
"Cumulative Medication Duration Greater Than or Equal to 180 Days"
( ["Encounter, Performed": "Office Visit"] union ["Encounter, Performed": "Preventive Care Services Established Office Visit, 18 and Up"] union ["Encounter, Performed": "Preventive Care Services Initial Office Visit, 18 and Up"] union ["Encounter, Performed": "Home Healthcare Services"] union ["Encounter, Performed": "Annual Wellness Visit"] union ["Encounter, Performed": "Nursing Facility Visit"] union ["Encounter, Performed": "Psych Visit Diagnostic Evaluation"] union ["Encounter, Performed": "Psych Visit Psychotherapy"] union ["Encounter, Performed": "Telephone Visits"] union ["Encounter, Performed": "Virtual Encounter"] ) ValidEncounter where date from start of ValidEncounter.relevantPeriod within 60 days of "IPSD"
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
case when Frequency ~ "Once daily (qualifier value)" then 1.0 when Frequency ~ "Twice a day (qualifier value)" then 2.0 when Frequency ~ "Three times daily (qualifier value)" then 3.0 when Frequency ~ "Four times daily (qualifier value)" then 4.0 when Frequency ~ "Every twenty four hours (qualifier value)" then 1.0 when Frequency ~ "Every twelve hours (qualifier value)" then 2.0 when Frequency ~ "Every thirty six hours (qualifier value)" then 0.67 when Frequency ~ "Every eight hours (qualifier value)" then 3.0 when Frequency ~ "Every four hours (qualifier value)" then 6.0 when Frequency ~ "Every six hours (qualifier value)" then 4.0 when Frequency ~ "Every seventy two hours (qualifier value)" then 0.33 when Frequency ~ "Every forty eight hours (qualifier value)" then 0.5 when Frequency ~ "Every eight to twelve hours (qualifier value)" then 3.0 when Frequency ~ "Every six to eight hours (qualifier value)" then 4.0 when Frequency ~ "Every three to four hours (qualifier value)" then 8.0 when Frequency ~ "Every three to six hours (qualifier value)" then 8.0 when Frequency ~ "Every two to four hours (qualifier value)" then 12.0 when Frequency ~ "One to four times a day (qualifier value)" then 4.0 when Frequency ~ "One to three times a day (qualifier value)" then 3.0 when Frequency ~ "One to two times a day (qualifier value)" then 2.0 when Frequency ~ "Two to four times a day (qualifier value)" then 4.0 else null end
if Intervals is not null then ( Sum((collapse Intervals per day)X return all(difference in days between start of X and end of X )+ 1 ) ) else null
MedDispense Dispense let startDate: date from Coalesce(Dispense.relevantPeriod.low, Dispense.relevantDatetime, Dispense.authorDatetime), totalDaysSupplied: Coalesce(Dispense.daysSupplied, Dispense.supply.value /(Dispense.dosage.value * ToDaily(Dispense.frequency))) return if startDate is null then null else if totalDaysSupplied is not null then Interval[startDate, startDate + Quantity { value: totalDaysSupplied - 1, unit: 'day' }] else if Dispense.relevantPeriod.high is not null then Interval[startDate, date from end of Dispense.relevantPeriod] else null
case Frequency.unit when 'h' then (24.0 / Frequency.value) when 'min' then (24.0 / Frequency.value) * 60 when 's' then (24.0 / Frequency.value) * 60 * 60 when 'd' then (24.0 / Frequency.value) / 24 when 'wk' then (24.0 / Frequency.value) / (24 * 7) when 'mo' then (24.0 / Frequency.value) / (24 * 30) /* assuming 30 days in month */ when 'a' then (24.0 / Frequency.value) / (24 * 365) /* assuming 365 days in year */ when 'hour' then (24.0 / Frequency.value) when 'minute' then (24.0 / Frequency.value) * 60 when 'second' then (24.0 / Frequency.value) * 60 * 60 when 'day' then (24.0 / Frequency.value) / 24 when 'week' then (24.0 / Frequency.value) / (24 * 7) when 'month' then (24.0 / Frequency.value) / (24 * 30) /* assuming 30 days in month */ when 'year' then (24.0 / Frequency.value) / (24 * 365) /* assuming 365 days in year */ when 'hours' then (24.0 / Frequency.value) when 'minutes' then (24.0 / Frequency.value) * 60 when 'seconds' then (24.0 / Frequency.value) * 60 * 60 when 'days' then (24.0 / Frequency.value) / 24 when 'weeks' then (24.0 / Frequency.value) / (24 * 7) when 'months' then (24.0 / Frequency.value) / (24 * 30) /* assuming 30 days in month */ when 'years' then (24.0 / Frequency.value) / (24 * 365) /* assuming 365 days in year */ else null end
case when Frequency is Quantity then QuantityToDaily(Frequency as Quantity) else CodeToDaily(Frequency as Code) end
if pointInTime is not null then Interval[pointInTime, pointInTime] else if period is not null then period else null as Interval<DateTime>
Interval[date from start of period, date from end of period]
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
Measure Set |
None |
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