eCQM Title | Discharged on Antithrombotic Therapy |
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CMS ID | 104 | eCQM Version Number | 14.1.000 |
CBE Number | Not Applicable | GUID | 42bf391f-38a3-4c0f-9ece-dcd47e9609d9 |
Measurement Period | January 1, 2026 through December 31, 2026 | ||
Measure Steward | The Joint Commission | ||
Measure Developer | The Joint Commission | ||
Endorsed By | None | ||
Description |
Ischemic stroke patients prescribed or continuing to take antithrombotic therapy at hospital discharge |
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Copyright |
Measure specifications are in the Public Domain. LOINC(R) copyright 2004-2024 Regenstrief Institute, Inc. This material contains SNOMED Clinical Terms(R) (SNOMED CT[R]) copyright 2004-2024 International Health Terminology Standards Development Organisation. ICD-10 copyright 2024 World Health Organization. All Rights Reserved. |
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Disclaimer |
These performance measures are not clinical guidelines, do not establish a standard of medical care, and have not been tested for all potential applications. The measures and specifications are provided without warranty. |
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Measure Scoring | Proportion | ||
Measure Type | Process | ||
Stratification |
None |
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Risk Adjustment |
None |
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Rate Aggregation |
None |
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Rationale |
The effectiveness of antithrombotic agents in reducing stroke mortality, stroke-related morbidity and recurrence rates has been studied in several large clinical trials. While the use of these agents for patients with acute ischemic stroke and transient ischemic attacks continues to be the subject of study, substantial evidence is available from completed studies. Data at this time suggest that antithrombotic therapy should be prescribed at discharge following acute ischemic stroke to reduce stroke mortality and morbidity if no contraindications exist. For patients with a stroke due to a cardioembolic source (e.g., atrial fibrillation, mechanical heart valve), warfarin is recommended unless contraindicated. In recent years, novel oral anticoagulant agents (NOACs) have been developed and approved by the U.S. Food and Drug Administration (FDA) for stroke prevention and may be considered as an alternative to warfarin for select patients. Anticoagulation therapy is not generally recommended for secondary stroke prevention in patients presumed to have a non-cardioembolic stroke. Anticoagulants at doses to prevent venous thromboembolism are insufficient antithrombotic therapy to prevent recurrent ischemic stroke or transient ischemic attack (TIA). |
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Clinical Recommendation Statement |
Clinical trial results suggest that antithrombotic therapy should be prescribed at discharge following acute ischemic stroke to reduce stroke mortality and morbidity if no contraindications exist |
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Improvement Notation |
Increased score indicates improvement |
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Reference |
Reference Type: CITATION Reference Text: 'Adams, H. P., del Zoppo, G., Alberts, M. J., Bhatt, D. L., Brass, L., Furlan, A., . . . Wijdicks, E. F.M, (2007). Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke, 38(5), 1655–1711. https://doi.org/10.1161/STROKEAHA.107.181486' |
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Reference |
Reference Type: CITATION Reference Text: 'Adams, H., Adams, R., Del Zoppo, G., & Goldstein, L. B. (2005). Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke, 36(4), 916–923. https://doi.org/10.1161/01.STR.0000163257.66207.2d' |
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Reference |
Reference Type: CITATION Reference Text: 'Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., & Teal, P. (2001). Antithrombotic and thrombolytic therapy for ischemic stroke. Chest, 119(1 Suppl), 300S–320S. https://doi.org/10.1378/chest.119.1_suppl.300s.' |
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Reference |
Reference Type: CITATION Reference Text: 'Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., & Teal, P. (2004). Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest, 126(3 Suppl), 483S–512S. https://doi.org/10.1378/chest.126.3_suppl.483s' |
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Reference |
Reference Type: CITATION Reference Text: 'Antiplatelet Trialists’ Collaboration (1994). Collaborative overview of randomised trials of antiplatelet therapy—I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ, 308(6921), 81-106.' |
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Reference |
Reference Type: CITATION Reference Text: 'Antithrombotic Trialists’ Collaboration (2002). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients. BMJ (Clinical research ed.), 324(7329), 71-86. https://doi.org/10.1136/bmj.324.7329.71' |
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Reference |
Reference Type: CITATION Reference Text: 'Bhatt, D. L., Fox, K. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., . . . Topol, E. J. (2006). Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. New England Journal of Medicine, 354(16), 1706–1717. https://doi.org/10.1056/NEJMoa060989' |
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Reference |
Reference Type: CITATION Reference Text: 'Canadian Cooperative Study Group. (1978). A randomized trial of aspirin and sulfinpyrazone in threatened stroke. New England Journal of Medicine, 299(2), 53-59. https://doi.org/10.1056/NEJM197807132990201' |
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Reference |
Reference Type: CITATION Reference Text: 'CAPRIE Steering Committee. (1996). A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet , 348(9038), 1329-1339. https://doi.org/10.1016/s0140-6736(96)09457-3' |
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Reference |
Reference Type: CITATION Reference Text: 'Centers for Disease Control and Prevention. (2009). Prevalence and most common causes of disability among adults—United States, 2005. MMWR. Morbidity and mortality weekly report, 58(16), 421-426.' |
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Reference |
Reference Type: CITATION Reference Text: 'Chen, Z. M., Sandercock, P., Pan, H. C., Counsell, C., Collins, R., Liu, L. S., . . . Peto, R. (2000). Indications for early aspirin use in acute ischemic stroke: A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. Stroke, 31(6), 1240–1249. https://doi.org/10.1161/01.str.31.6.1240' |
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Reference |
Reference Type: CITATION Reference Text: 'Coull, B. M., Williams, L. S., Goldstein, L. B., Meschia, J. F., Heitzman, D., Chaturvedi, S., . . . (2002). Anticoagulants and antiplatelet agents in acute ischemic stroke: report of the Joint Stroke Guideline Development Committee of the American Academy of Neurology and the American Stroke Association (a division of the American Heart Association). Stroke, 33(7), 1934–1942. https://doi.org/10.1161/01.str.0000028456.18614.93' |
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Reference |
Reference Type: CITATION Reference Text: 'Diener, H. C., Bogousslavsky, J., Brass, L. M., Cimminiello, C., Csiba, L., Kaste, M., . . . Rupprecht, H. J. (2004). Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet, 364(9431), 331–337. https://doi.org/10.1016/S0140-6736(04)16721-4' |
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Reference |
Reference Type: CITATION Reference Text: 'Dutch TIA Trial Study Group, van Gijn, J., Algra, A., Kappelle, J., Koudstaal, P. J., & van Latum, A. (1991). A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. New England Journal of Medicine, 325(18), 1261–1266. https://doi.org/10.1056/NEJM199110313251801' |
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Reference |
Reference Type: CITATION Reference Text: 'Eccles, M., Freemantle, N., & Mason, J. (1998). North of England Evidence-Based Guideline Development Project: Guideline on the use of aspirin as secondary prophylaxis for vascular disease in primary care. BMJ (Clinical research ed), 316(7140), 1303-1309. https://doi.org/10.1136/bmj.316.7140.1303' |
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Reference |
Reference Type: CITATION Reference Text: 'ESPRIT Study Group, Halkes, P. H., van Gijn, J., Kappelle, L. J., Koudstaal, P. J., & Algra, A. (2006). Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet, 367(9523), 1665–1673. https://doi.org/10.1016/S0140-6736(06)68734-5' |
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Reference |
Reference Type: CITATION Reference Text: 'Farrell, B., Godwin, J., Richards, S., & Warlow, C. (1991). The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. Journal of Neurology, Neurosurgery, & Psychiatry, 54(12), 1044–1054. https://doi.org/10.1136/jnnp.54.12.1044' |
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Reference |
Reference Type: CITATION Reference Text: 'Gaspoz, J. M., Coxson, P. G., Goldman, P. A., Williams, L. W., Kuntz, K. M., Hunink, M. G., & Goldman, L. (2002). Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. New England Journal of Medicine, 346(23), 1800–1806. https://doi.org/10.1056/NEJM200206063462309' |
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Reference |
Reference Type: CITATION Reference Text: 'Gent, M., Donald Easton, J., Hachinski, V. C., Panak, E., Sicurella, J., Blakely, J. A., . . . Turpie, A. G. (1989). The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1(8649), 1215–1220. https://doi.org/10.1016/s0140-6736(89)92327-1' |
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Reference |
Reference Type: CITATION Reference Text: 'Gorelick, P. B., Richardson, D., Kelly, M., Ruland, S., Hung, E., Harris, Y., . . . Leurgans, S. (2003). Aspirin and ticlopidine for prevention of recurrent stroke in black patients: a randomized trial. JAMA, 289(22), 2947–2957. https://doi.org/10.1001/jama.289.22.2947' |
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Reference |
Reference Type: CITATION Reference Text: 'Guyatt, G. H., Akl, E. A., Crowther, M., Gutterman, D. D., Schuünemann, H. J., (2012). Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141(2 Suppl), 7S–47S. https://doi.org/10.1378/chest.1412S3'' |
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Reference |
Reference Type: CITATION Reference Text: 'Guyatt, G., Schunëmann, H., Cook, D., Jaeschke, R., Pauker, S., Bucher, H., (2001). Grades of recommendation for antithrombotic agents. Chest, 119(1 Suppl), 3S–7S. https://doi.org/10.1378/chest.119.1_suppl.3s' |
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Reference |
Reference Type: CITATION Reference Text: 'Hass, W. K., Easton, J. D., Adams, H. P., Jr, Pryse-Phillips, W., Molony, B. A., Anderson, S., & Kamm, B. (1989). A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. New England Journal of Medicine, 321(8), 501–507. https://doi.org/10.1056/NEJM198908243210804' |
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Reference |
Reference Type: CITATION Reference Text: 'International Stroke Trial Collaborative Group. (1997). The International Stroke Trial (IST): A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. Lancet, 349(9065), 1569-1581.' |
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Reference |
Reference Type: CITATION Reference Text: 'Jauch, E. C., Saver, J. L., Adams, H. P., Jr, Bruno, A., Connors, J. J., Demaerschalk, B. M., . . . Yonas, H. , Council on Peripheral Vascular Disease, & Council on Clinical Cardiology (2013). Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 44(3), 870–947. https://doi.org/10.1161/STR.0b013e318284056a' |
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Reference |
Reference Type: CITATION Reference Text: 'Johnson, E. S., Lanes, S. F., Wentworth, C. E., 3rd, Satterfield, M. H., Abebe, B. L., & Dicker, L. W. (1999). A metaregression analysis of the dose-response effect of aspirin on stroke. Archives of Internal Medicine, 159(11), 1248–1253. https://doi.org/10.1001/archinte.159.11.1248' |
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Reference |
Reference Type: CITATION Reference Text: 'Kennedy, J., Hill, M. D., Ryckborst, K. J., Eliasziw, M., Demchuk, A. M., & Buchan, A. M., (2007). Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. The Lancet. Neurology, 6(11), 961–969. https://doi.org/10.1016/S1474-4422(07)70250-8' |
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Reference |
Reference Type: CITATION Reference Text: 'Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., . . . Wilson, J. A. (2014). Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 45(7), 2160–2236. https://doi.org/10.1161/STR.0000000000000024' |
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Reference |
Reference Type: CITATION Reference Text: 'Kleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., ... Williams, L. S. (2021). 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: A guideline from the American Heart Association/American Stroke Association. Stroke, 52(7), e364-e467. https://doi.org/10.1161/STR.0000000000000375' |
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Reference |
Reference Type: CITATION Reference Text: 'Powers, W. J., Rabinstein, A. A., Ackerson, T., Adeoye, O. M., Bambakidis, N. C., Becker, K., . . . Tirschwell, D. L. (2018). 2018 Guidelines for the early management of patients With acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 49(3), e46–e110. https://doi.org/10.1161/STR.0000000000000158' |
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Reference |
Reference Type: CITATION Reference Text: 'Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., . . . Turner, M. B. (2012). Heart disease and stroke statistics—2012 update: A report from the American Heart Association. Circulation, 125(1), e2-e220. https://doi.org/10.1161/CIR.0b013e31823ac046' |
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Reference |
Reference Type: CITATION Reference Text: 'Sacco, R. L., Diener, H. C., Yusuf, S., Cotton, D., Ounpuu, S., Lawton, W. A., . . . Yoon, B. (2008). Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New England Journal of Medicine, 359(12), 1238-1251. https://doi.org/10.1056/NEJMoa0805002' |
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Reference |
Reference Type: CITATION Reference Text: 'The European Stroke Prevention Study (ESPS). Principal end-points. The ESPS Group. (1987). Lancet, 2(8572), 1351–1354.' |
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Reference |
Reference Type: CITATION Reference Text: 'The SALT Collaborative Group (1991). Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet, 338(8779), 1345-1349.' |
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Reference |
Reference Type: CITATION Reference Text: 'UK-Tia Study Group. (1988). United Kingdom Transient Ischaemic Attack (UK-Tia) Aspirin Trial: Interim results. British Medical Journal (Clinical research ed.), 296(6618), 316-320.' |
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Definition |
None |
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Guidance |
The "Nonelective Inpatient Encounter" value set intends to capture all non-scheduled hospitalizations. This value set is a subset of the "Inpatient encounter" value set, excluding concepts that specifically refer to elective hospital admissions. Non-elective admissions include emergency, urgent and unplanned admissions. The "Medication, Discharge" datatype refers to the discharge medication list and is intended to express medications ordered for post-discharge use. The denominator population includes patients with inpatient hospitalizations and patients from Acute Hospital Care at Home programs, who are treated and billed as inpatients but receive care in their home. This eCQM is an episode-based measure. An episode is defined as each inpatient hospitalization or encounter that ends during the measurement period. This version of the eCQM uses QDM version 5.6. Please refer to the eCQI resource center (https://ecqi.healthit.gov/qdm) for more information on the QDM. |
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Transmission Format |
TBD |
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Initial Population |
Inpatient hospitalizations (non-elective admissions) for patients age 18 and older, discharged from inpatient care with a principal diagnosis of ischemic stroke, ending during the measurement period |
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Denominator |
Equals Initial Population |
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Denominator Exclusions |
- Inpatient hospitalizations for patients admitted for elective carotid intervention. This exclusion is implicitly modeled by only including non-elective hospitalizations. - Inpatient hospitalizations for patients discharged to another hospital - Inpatient hospitalizations for patients who left against medical advice - Inpatient hospitalizations for patients who expired - Inpatient hospitalizations for patients discharged to home for hospice care - Inpatient hospitalizations for patients discharged to a health care facility for hospice care - Inpatient hospitalizations for patients with comfort measures documented |
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Numerator |
Inpatient hospitalizations for patients prescribed or continuing to take antithrombotic therapy at hospital discharge |
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Numerator Exclusions |
None |
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Denominator Exceptions |
- Inpatient hospitalizations for patients with a documented reason for not prescribing antithrombotic therapy at discharge - Inpatient hospitalizations for patients who receive Prasugrel as an antithrombotic therapy at discharge |
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Supplemental Data Elements |
For every patient evaluated by this measure also identify payer, race, ethnicity and sex |
TJC."Ischemic Stroke Encounter"
"Initial Population"
TJC."Ischemic Stroke Encounters With Discharge Disposition" union TJC."Encounter With Comfort Measures During Hospitalization"
TJC."Ischemic Stroke Encounter" IschemicStrokeEncounter with ["Medication, Discharge": "Antithrombotic Therapy for Ischemic Stroke"] DischargeAntithrombotic such that DischargeAntithrombotic.authorDatetime during IschemicStrokeEncounter.relevantPeriod
None
"Encounter With Documented Reason For No Antithrombotic At Discharge" union "Encounter With Pharmacological Contraindications For Antithrombotic Therapy At Discharge"
None
"Initial Population"
"Encounter With Documented Reason For No Antithrombotic At Discharge" union "Encounter With Pharmacological Contraindications For Antithrombotic Therapy At Discharge"
TJC."Ischemic Stroke Encounters With Discharge Disposition" union TJC."Encounter With Comfort Measures During Hospitalization"
TJC."Ischemic Stroke Encounter" IschemicStrokeEncounter with "Reason For Not Giving Antithrombotic At Discharge" NoDischargeAntithrombotic such that NoDischargeAntithrombotic.authorDatetime during IschemicStrokeEncounter.relevantPeriod
TJC."Ischemic Stroke Encounter" IschemicStrokeEncounter with ["Medication, Discharge": "Pharmacological Contraindications For Antithrombotic Therapy"] PharmacologicalContraindications such that PharmacologicalContraindications.authorDatetime during IschemicStrokeEncounter.relevantPeriod
TJC."Ischemic Stroke Encounter"
TJC."Ischemic Stroke Encounter" IschemicStrokeEncounter with ["Medication, Discharge": "Antithrombotic Therapy for Ischemic Stroke"] DischargeAntithrombotic such that DischargeAntithrombotic.authorDatetime during IschemicStrokeEncounter.relevantPeriod
["Medication, Not Discharged": "Antithrombotic Therapy for Ischemic Stroke"] NoAntithromboticDischarge where NoAntithromboticDischarge.negationRationale in "Medical Reason For Not Providing Treatment" or NoAntithromboticDischarge.negationRationale in "Patient Refusal"
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "Federal Administrative Sex"]
"Ischemic Stroke Encounter" IschemicStrokeEncounter with "Intervention Comfort Measures" ComfortMeasure such that Coalesce(start of Global."NormalizeInterval"(ComfortMeasure.relevantDatetime, ComfortMeasure.relevantPeriod), ComfortMeasure.authorDatetime)during Global."HospitalizationWithObservation" ( IschemicStrokeEncounter )
["Intervention, Order": "Comfort Measures"] union ["Intervention, Performed": "Comfort Measures"]
"Non Elective Encounter With Age" NonElectiveEncounterWithAge where exists ( NonElectiveEncounterWithAge.diagnoses Diagnosis where Diagnosis.code in "Ischemic Stroke" and Diagnosis.rank = 1 )
( ( "Ischemic Stroke Encounter" IschemicStrokeEncounter where IschemicStrokeEncounter.dischargeDisposition in "Discharge To Acute Care Facility" or IschemicStrokeEncounter.dischargeDisposition in "Left Against Medical Advice" or IschemicStrokeEncounter.dischargeDisposition in "Patient Expired" or IschemicStrokeEncounter.dischargeDisposition in "Discharged to Home for Hospice Care" or IschemicStrokeEncounter.dischargeDisposition in "Discharged to Health Care Facility for Hospice Care" ) )
["Encounter, Performed": "Nonelective Inpatient Encounter"] NonElectiveEncounter where AgeInYearsAt(date from start of NonElectiveEncounter.relevantPeriod) >= 18 and NonElectiveEncounter.relevantPeriod ends during day of "Measurement Period"
Encounter Visit let ObsVisit: Last(["Encounter, Performed": "Observation Services"] LastObs where LastObs.relevantPeriod ends 1 hour or less on or before start of Visit.relevantPeriod sort by end of relevantPeriod ), VisitStart: Coalesce(start of ObsVisit.relevantPeriod, start of Visit.relevantPeriod), EDVisit: Last(["Encounter, Performed": "Emergency Department Visit"] LastED where LastED.relevantPeriod ends 1 hour or less on or before VisitStart sort by end of relevantPeriod ) return Interval[Coalesce(start of EDVisit.relevantPeriod, VisitStart), end of Visit.relevantPeriod]
if pointInTime is not null then Interval[pointInTime, pointInTime] else if period is not null then period else null as Interval<DateTime>
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "Federal Administrative Sex"]
Measure Set |
eMeasure Stroke (eSTK) |
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